The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025
Pregnancy complicated by Factor XII deficiency: a case report and literature review.
Клинический случайСтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Su Yunyi, Wu XueMei, Wu Xian, Li Yaojie, Xie Aijie, Jiang Xia, Zhou XinE, Yu Xia, Gan Xiaoqin
Аннотация
BACKGROUND: Factor XII deficiency, a rare inherited coagulation disorder, typically presents with isolated prolonged activated partial thromboplastin tim without spontaneous bleeding. Paradoxically, it is associated with thrombotic events and adverse pregnancy outcomes. Evidence-based guidelines for managing FXII deficiency in pregnancy remain lacking.
CASE PRESENTATION: A 27-year-old primigravida was incidentally diagnosed with severe FXII deficiency during routine prenatal screening. At 38+5 weeks, she presented with vaginal spotting and spontaneous rupture of membranes. A multidisciplinary team planned a cesarean delivery under general anesthesia. Prophylactic fresh frozen plasma (FFP) 400 mL was administered preoperatively. Postoperative FFP (400 mL) was transfused. No bleeding & thrombotic complications occurred in the mother or neonate.
SYSTEMATIC REVIEW: Analysis of 9 publications (19 pregnancies) revealed.
CONCLUSIONS: Successful perinatal outcomes hinge on multidisciplinary collaboration, dynamic risk stratification, and personalized bleeding-thrombosis balance. Prophylactic FFP with selective LMWH demonstrated safety in this case. Further studies are needed to optimize standardized pathways.
CASE PRESENTATION: A 27-year-old primigravida was incidentally diagnosed with severe FXII deficiency during routine prenatal screening. At 38+5 weeks, she presented with vaginal spotting and spontaneous rupture of membranes. A multidisciplinary team planned a cesarean delivery under general anesthesia. Prophylactic fresh frozen plasma (FFP) 400 mL was administered preoperatively. Postoperative FFP (400 mL) was transfused. No bleeding & thrombotic complications occurred in the mother or neonate.
SYSTEMATIC REVIEW: Analysis of 9 publications (19 pregnancies) revealed.
CONCLUSIONS: Successful perinatal outcomes hinge on multidisciplinary collaboration, dynamic risk stratification, and personalized bleeding-thrombosis balance. Prophylactic FFP with selective LMWH demonstrated safety in this case. Further studies are needed to optimize standardized pathways.