Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts.

BACKGROUND

Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts.

AIM: To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts.

METHODS

Twenty patients with single or multiple plantar warts were included in this study. Vitamin D(3) (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals.

RESULTS

In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed.

CONCLUSION

Intralesional vitamin D(3) may be an effective treatment option for warts.