Cantharidin: Its Role in Dermatology Revisited.

Dermatologists have been using cantharidin as a vesicant for the treatment of molluscum contagiosum and warts since the 1950s. In experienced hands, treatment with cantharidin is safe, effective, and rarely associated with significant complications. There are varying methods of application and treatment regimens among practitioners; a consensus standard of care has yet to be established. This article provides an overview of cantharidin and its role in dermatology with an emphasis on mechanism of action, adverse effects, limitations of use, and how it compares with alternative treatment options. Instructions for topical application and other important considerations surrounding its use are also discussed.