[Effect of trace element deficiency on metalloenzyme activity and the growth of Guerin carcinoma].

The selective deficiency of manganese, copper, zinc and silicon in the diet of animals essentially decreases the content of the corresponding element in the organism tissues and disturbs the activity of some blood metalloenzymes in tumour-carrying animals. The tumour tissue retains the metals under study in higher amounts. When rats are given the diet with copper deficiency, there are no essential changes in the growth of Guerin carcinoma, whereas deficiency of manganese, silicon and particularly in zinc in the animal diet causes an inhibition of its growth. The tumour growth is shown possible to be affected by the diet deficient in trace elements, silicon and zinc in particular.