International journal of psychiatry in medicine · 2001
An organic psychosis due to a venlafaxine-propafenone interaction.
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Pfeffer F, Grube M
Аннотация
OBJECTIVE: An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder.
METHODS: Clinical observation and further investigations including monitoring of serum levels (case report).
RESULTS: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes.
CONCLUSIONS: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.
METHODS: Clinical observation and further investigations including monitoring of serum levels (case report).
RESULTS: A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes.
CONCLUSIONS: There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.