Diphencyprone in the management of refractory palmoplantar and periungual warts: an open study.

BACKGROUND

Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities.

OBJECTIVE

We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts.

METHODS

From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered.

RESULTS

The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and 18 partial remissions. The rate of positive responders (60%) compares with the results published by other authors.

CONCLUSION

Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.