Медицинская библиотека · International microbiology : the official journal of the Spanish Society for Microbiology · 2022

Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis.

Chatterjee Kuhu, Taneja Juhi, Khullar Shilpa, Pandey Anil Kumar

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Аннотация

INTRODUCTION

The present study aimed to investigate the antifungal activity of silver nanoparticles (SNPs) against agents of suspected rhino orbital mucormycosis.

METHODS

Thirty-two strains were isolated from endoscopy-guided nasal swab and/or tissue biopsy after debridement/surgery on Sabouraud dextrose agar without cyclohexamide. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute's (CLSI) guidelines, M38-A2. The average size of silver nanoparticle was less than 10 nm.

RESULTS

Minimum inhibitory concentration (MIC) of nanoparticles of all strains was in the concentration range of 1-64 μg/ml and minimal fungicidal concentration (MFC) at 16-512 μg/ml.

CONCLUSION

The SNPs revealed significant antifungal activity against agents of invasive mycosis.

Для цитирования: Chatterjee Kuhu, Taneja Juhi, Khullar Shilpa, Pandey Anil Kumar. Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis.. International microbiology : the official journal of the Spanish Society for Microbiology. 2022. DOI: 10.1007/s10123-022-00280-7.

Предметные рубрики MeSH

Humans Antifungal Agents Metal Nanoparticles Silver Mucormycosis Microbial Sensitivity Tests

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