Biological & pharmaceutical bulletin · 2004
Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Ikeya Yukinobu, Takeda Shigefumi, Tunakawa Mitsuo, Karakida Humito, Toda Kouin, Yamaguchi Takuji, Aburada Masaki
Аннотация
We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia Willdenow, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of P. tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound 1 has cognitive improving and cerebral protective effects.