Noninfectious complications of common variable immune deficiency.

Background

Common variable immune deficiency (CVID) is a primary immune deficiency due to defective B-cell maturation.

Objective

To improve recognition of noninfectious complications of CVID and increase awareness of appropriate interventions for noninfectious complications of CVID.

Methods

To review the diagnosis and treatment of CVID with infectious and noninfectious complications.

Results

A case of a woman with CVID with autoimmunity and gastrointestinal complications is presented with a discussion of the recognition and treatment of infectious and noninfectious complications.

Conclusion

Patients with CVID must be monitored for noninfectious complications, e.g., inflammatory disease of the lung and gastrointestinal tract, because these are associated with decreased survival.