Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study.

BACKGROUND

Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.

OBJECTIVE

To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.

METHODS

In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.

RESULTS

Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.

CONCLUSION

Biomarkers associated with AKI following CPB may merit further study.