Archives of virology · 2026
Lineage replacement of coxsackievirus A10 in Vietnam associated with increased detection and altered disease severity grading of hand, foot, and mouth disease.
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Nguyen Anh The, Ta Hong Thi Thu, Dao Anh Thi Hai, Vu Hung Manh, Ngu Nghia Duy, Tran Duong Nhu, Shimizu Hiroyuki, Nishimura Yorihiro, Hoa-Tran Thi Nguyen
Аннотация
Coxsackievirus A10 (CV-A10) has become an important cause of hand, foot, and mouth disease (HFMD). Molecular surveillance in northern Vietnam during 2018–2020 revealed the introduction and rapid dominance of the genotype C lineage (CHN), replacing the previously endemic lineage (VNM). This shift was associated with a significant increase in detection and altered clinical severity, predominantly grade 2A (83.8%). Phylogenetic analysis revealed the close relatedness between the emerging Vietnamese strains and those circulating in China (2017–2024). These findings suggest lineage-dependent virulence in CV-A10, highlighting the need for lineage-level molecular surveillance to guide HFMD control and vaccine development.