Медицинская библиотека · Memorias do Instituto Oswaldo Cruz · 2023

First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil.

Rêgo Felipe Dutra, da Silva Eduardo Sérgio, Lopes Valeriana Valadares, Teixeira-Neto Rafael Gonçalves, Belo Vinícius Silva, Fonseca Júnior Antônio Augusto, Pereira Diego Andrade, Pena Heber Paulino, Laurenti Márcia Dalastra, Araújo Gabriela V, da Matta Vânia Lúcia Ribeiro, Chouman Islam Hussein, Burrin Thainá Bergantin, Sandoval Carmen M, Barrouin-Melo Stella Maria, de Pinho Flaviane Alves, de Andrade Hélida Monteiro, Nunes Ramon Vieira, Gontijo Célia Maria Ferreira, Soccol Vanete Thomaz, Klocek Donnamae, Grybchuk Danyil, Macedo Diego Henrique, do Monte-Neto Rubens Lima, Yurchenko Vyacheslav, Soares Rodrigo Pedro

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Аннотация

BACKGROUND

Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania.

OBJECTIVES

In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions.

METHODS

A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene.

FINDINGS: We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively.

MAIN

CONCLUSIONS

To the best of our knowledge, this is the first detection of LRV2 in the New World.

Для цитирования: Rêgo Felipe Dutra, da Silva Eduardo Sérgio, Lopes Valeriana Valadares, Teixeira-Neto Rafael Gonçalves, Belo Vinícius Silva, Fonseca Júnior Antônio Augusto, Pereira Diego Andrade, Pena Heber Paulino, Laurenti Márcia Dalastra, Araújo Gabriela V, da Matta Vânia Lúcia Ribeiro, Chouman Islam Hussein, Burrin Thainá Bergantin, Sandoval Carmen M, Barrouin-Melo Stella Maria, de Pinho Flaviane Alves, de Andrade Hélida Monteiro, Nunes Ramon Vieira, Gontijo Célia Maria Ferreira, Soccol Vanete Thomaz, Klocek Donnamae, Grybchuk Danyil, Macedo Diego Henrique, do Monte-Neto Rubens Lima, Yurchenko Vyacheslav, Soares Rodrigo Pedro. First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil.. Memorias do Instituto Oswaldo Cruz. 2023. DOI: 10.1590/0074-02760230071.

Предметные рубрики MeSH

Humans Animals Dogs Leishmania infantum Leishmaniasis, Visceral Brazil RNA-Dependent RNA Polymerase

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