Exploring molecular pathways in Alzheimer's disease neurodegeneration using biomarkers.

The need to better understand the role of tumor necrosis factor-alpha (TNF-α) in Alzheimer's disease (AD) and its relationship with brain atrophy and cognitive decline is highly relevant. Therefore, it is of interest to investigate the role of tumor necrosis factor-alpha (TNF-α) in Alzheimer's disease (AD) by analyzing its relationship with brain atrophy and cognitive decline in 80 AD patients. Our results show a significant correlation between increased CSF TNF-α levels and hippocampal atrophy. Additionally, TNF-α level were associated with other clinical variables, emphasizing its role in neuroinflammation. Thus, TNF-α as a potential biomarker for Alzheimer's disease progression. Further research is needed to assess its therapeutic potential. The advancement to knowledge in this study is the identification of a significant correlation between elevated TNF-α levels and hippocampal atrophy in Alzheimer's disease, supporting TNF-α as a potential biomarker for disease progression.