Clinical characteristics of allergic bronchopulmonary mycosis caused by Schizophyllum commune.
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Oguma Tsuyoshi, Ishiguro Takashi, Kamei Katsuhiko, Tanaka Jun, Suzuki Junko, Hebisawa Akira, Obase Yasushi, Mukae Hiroshi, Tanosaki Takae, Furusho Shiho, Kurokawa Koji, Watai Kentaro, Matsuse Hiroto, Harada Norihiro, Nakamura Ai, Shibayama Takuo, Baba Rie, Fukunaga Kentaro, Matsumoto Hisako, Ohba Hisano, Sakamoto Susumu, Suzuki Shinko, Tanaka Shintetsu, Yamada Takahiro, Yamasaki Akira, Fukutomi Yuma, Shiraishi Yoshiki, Toyotome Takahito, Fukunaga Koichi, Shimoda Terufumi, Konno Satoshi, Taniguchi Masami, Tomomatsu Katsuyoshi, Okada Naoki, Asano Koichiro, Japan ABPM Research Program
Аннотация
OBJECTIVE: Herein, we attempted to clarify the clinical characteristics of ABPM caused by S. commune (ABPM-Sc) compared with those of allergic bronchopulmonary aspergillosis (ABPA).
METHODS: Patients with ABPM-Sc or ABPA were recruited from a nationwide survey in Japan, a multicenter cohort, and a fungal database at the Medical Mycology Research Center of Chiba University. The definition of culture-positive ABPM-Sc/ABPA is as follows: (1) fulfills five or more of the 10 diagnostic criteria for ABPM proposed by Asano et al., and (2) positive culture of S. commune/Aspergillus spp. in sputum, bronchial lavage fluid, or mucus plugs in the bronchi.
RESULTS: Thirty patients with ABPM-Sc and 46 with ABPA were recruited. Patients with ABPM-Sc exhibited less severe asthma and presented with better pulmonary function than those with ABPA (p = 0.008-0.03). Central bronchiectasis was more common in ABPM-Sc than that in ABPA, whereas peripheral lung lesions, including infiltrates/ground-glass opacities or fibrotic/cystic changes, were less frequent in ABPM-Sc. Aspergillus fumigatus-specific immunoglobulin (Ig)E was negative in 10 patients (34%) with ABPM-Sc, who demonstrated a lower prevalence of asthma and levels of total serum IgE than those with ABPM-Sc positive for A. fumigatus-specific IgE or ABPA.
CONCLUSIONS: Clinical characteristics of ABPM-Sc, especially those negative for A. fumigatus-specific IgE, differed from those of ABPA.