The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Alizamini Mirmohammadali Mirramezani, Li Yonghui, Zhang Jian-Jun, Liang Jing, Haghparast Abbas
Аннотация
AIM: This review aims to summarise the role of endocannabinoid system (ECS), incluing cannabinoid receptors and their endogenous lipid ligands in the modulation of methamphetamine (METH)/morphine-induced memory impairments.
METHODS: Here, we utilized the results from researches which have investigated regulatory role of ECS (including cannabinoid receptor agonists and antagonists) on METH/morphine-induced memory impairments.
RESULTS: Among the neurotransmitters, glutamate and dopamine seem to play a critical role in association with the ECS to heal the drug-induced memory damages. Also, the amygdala, hippocampus, and prefrontal cortex are three important brain regions that participate in both drug addiction and memory task processes, and endocannabinoid neurotransmission have been investigated.
CONCLUSION: ECS can be regarded as a treatment for the side effects of METH and morphine, and their memory-impairing effects.
METHODS: Here, we utilized the results from researches which have investigated regulatory role of ECS (including cannabinoid receptor agonists and antagonists) on METH/morphine-induced memory impairments.
RESULTS: Among the neurotransmitters, glutamate and dopamine seem to play a critical role in association with the ECS to heal the drug-induced memory damages. Also, the amygdala, hippocampus, and prefrontal cortex are three important brain regions that participate in both drug addiction and memory task processes, and endocannabinoid neurotransmission have been investigated.
CONCLUSION: ECS can be regarded as a treatment for the side effects of METH and morphine, and their memory-impairing effects.