American journal of ophthalmology · 2026
Safety and Efficiency Reducing Retinopathy of Prematurity Guideline Sensitivity: An External Validation Using a Large US-based Dataset.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Arnold Robert W, Jacob Jack, Siegel Lance, Lee Thomas, Hutchinson Amy, Adams Carolina
Аннотация
PURPOSE: Recent publications have proposed alternative retinopathy of prematurity (ROP) screening guidelines balancing efficiency with safety. We used the 28-hospital ROP CheckⓇ higher-risk, racially diverse database to perform external validation. ROP Check is neonatology/ophthalmology software that combines customizable, guideline-based screening and ophthalmology monitoring of staging ROP examinations and treatment.
DESIGN: Retrospective analysis of screening guideline sensitivity.
METHODS: We reviewed encounter volumes from 2010 to 2022 of infants whose entire hospital stay was monitored with ROP Check. Patients with primary laser or anti-vascular endothelial growth factor (anti-VEGF) therapy were compared with recent-encounter volume-reducing (2%-8.6%) proposals.
RESULTS: A total of 5058 infants had 23,557 physician-patient encounters. Of these, 388 infants required ROP treatment, including 3 patients (1 of Pacific and 2 of non-Pacific race/ethnicity) with gestational age (GA) of 30.0 to 30.9 weeks. The 174 patients treated initially with laser had larger median bodyweight (BW) (706 g) than the 214 initially treated with anti-VEGF (620 g), older GA (25.1 vs 24.4 weeks), older GA at initial treatment (36.6 vs 35 weeks), fewer encounters (10 vs 13), and fewer examinations after treatment (3 vs 7). Six cases reached stage 4. We raise concerns that some of our treatment-warranted infants reached the threshold for treatment before the GA recommended by some recently proposed screening guideline modifications. However, cutting the last half-week GA screening guideline reduced encounters by 2.5%, whereas using ROP Check "if necessary" for BW <1400 and GA <30 weeks for infants of non-Pacific races/ethnicities cut encounters 7.8% without missing treatable infants.
CONCLUSIONS: The proposed modifications of currently accepted screening guidelines for premature infants in the United States could reduce the volume of encounters, but must account for high-risk Pacific race/ethnicity infants, who require more sensitive screening.
DESIGN: Retrospective analysis of screening guideline sensitivity.
METHODS: We reviewed encounter volumes from 2010 to 2022 of infants whose entire hospital stay was monitored with ROP Check. Patients with primary laser or anti-vascular endothelial growth factor (anti-VEGF) therapy were compared with recent-encounter volume-reducing (2%-8.6%) proposals.
RESULTS: A total of 5058 infants had 23,557 physician-patient encounters. Of these, 388 infants required ROP treatment, including 3 patients (1 of Pacific and 2 of non-Pacific race/ethnicity) with gestational age (GA) of 30.0 to 30.9 weeks. The 174 patients treated initially with laser had larger median bodyweight (BW) (706 g) than the 214 initially treated with anti-VEGF (620 g), older GA (25.1 vs 24.4 weeks), older GA at initial treatment (36.6 vs 35 weeks), fewer encounters (10 vs 13), and fewer examinations after treatment (3 vs 7). Six cases reached stage 4. We raise concerns that some of our treatment-warranted infants reached the threshold for treatment before the GA recommended by some recently proposed screening guideline modifications. However, cutting the last half-week GA screening guideline reduced encounters by 2.5%, whereas using ROP Check "if necessary" for BW <1400 and GA <30 weeks for infants of non-Pacific races/ethnicities cut encounters 7.8% without missing treatable infants.
CONCLUSIONS: The proposed modifications of currently accepted screening guidelines for premature infants in the United States could reduce the volume of encounters, but must account for high-risk Pacific race/ethnicity infants, who require more sensitive screening.