SICKLE as a holistic treatment approach to sickle cell disease related ulcers.

This article introduces a simple approach to adopt in the treatment of sickle cell disease (SCD) related ulcerations based on the acronym SICKLE, standing for Skin assessment, Infection control, Compression, Keep moving keep debriding, Local strapping and Endless support. This case report explains and describes each step used in the treatment of this challenging disease in a 24-year-old patient, achieving complete healing in 6 months in long-lasting SCD ulceration previously treated without results with many other treatments. It has been replicated in further patients with excellent results. The SICKLE approach is an attempt to deliver a holistic way of treating patients with SCD-related leg ulcers. More studies are needed to better define the scientific validity of this method or to demonstrate any inconsistencies.