Annales de pathologie · 2025
[About two cases of diffuse pulmonary meningotheliomatosis in female patients operated on for lung adenocarcinoma].
СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод пока не подготовлен
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Yguel Clémence, Marchal Aude, Mouget Bruno, Maadi Faïçal, Caput Brice, Cazes Aurélie, Guyard Alice
Аннотация
INTRODUCTION: Meningothelial-type pulmonary nodules are benign and relatively common, often incidentally discovered in nearly half of properly sampled lobectomy specimens. Diffused pulmonary meningotheliomatosis is a very rare condition, the origin of which remains unknown.
CASE PRESENTATION: We report two cases of disseminated pulmonary meningotheliomatosis in female patients, discovered during a lobectomy for bronchopulmonary adenocarcinoma. The diagnosis was made based on the surgical specimen, which presented multiple scattered nodules measuring 1 to 6mm with no peribronchial or subpleural pattern. The preoperative assessment revealed an associated intracranial meningioma in one patient. The other patient had chronic pulmonary inflammatory disease associated with smoking. In the two patients, there was no obvious clinical impact attributable to these disseminated micronodules.
DISCUSSION: Through these two cases, we propose to review the main characteristics of this rare condition and the etiological hypotheses.
CASE PRESENTATION: We report two cases of disseminated pulmonary meningotheliomatosis in female patients, discovered during a lobectomy for bronchopulmonary adenocarcinoma. The diagnosis was made based on the surgical specimen, which presented multiple scattered nodules measuring 1 to 6mm with no peribronchial or subpleural pattern. The preoperative assessment revealed an associated intracranial meningioma in one patient. The other patient had chronic pulmonary inflammatory disease associated with smoking. In the two patients, there was no obvious clinical impact attributable to these disseminated micronodules.
DISCUSSION: Through these two cases, we propose to review the main characteristics of this rare condition and the etiological hypotheses.