Terapevticheskii arkhiv · 1999
[Clinical, bactericidal and pharmacological evaluation of the effects of netromycin].
Клиническое исследованиеСравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Sokolova V I, Orlov V A, Fomina I P
Аннотация
AIM: To analyze clinical, bactericidal effectiveness and pharmacokinetics of wide-spectrum antibiotic netromycin (NM).
MATERIALS AND METHODS: The trial entered 29 patients: 21 with bronchopulmonary diseases (pneumonia and chronic bronchitis), 5 with exacerbation of chronic pyelonephritis, 2 with infectious endocarditis and 1 with peritonsillar abscess.
RESULTS: Microbiologically, most of the agents (80.36%) showed sensitivity to NM. Pharmacologically, NM persisted long in blood serum and sputum irrespective of the administration mode. Positive clinical dynamics after NM treatment was achieved in all the patients but one who had a peritonsillar abscess.
CONCLUSION: NM is highly active against both gram-positive and gram-negative flora. Side effects are minimal.
MATERIALS AND METHODS: The trial entered 29 patients: 21 with bronchopulmonary diseases (pneumonia and chronic bronchitis), 5 with exacerbation of chronic pyelonephritis, 2 with infectious endocarditis and 1 with peritonsillar abscess.
RESULTS: Microbiologically, most of the agents (80.36%) showed sensitivity to NM. Pharmacologically, NM persisted long in blood serum and sputum irrespective of the administration mode. Positive clinical dynamics after NM treatment was achieved in all the patients but one who had a peritonsillar abscess.
CONCLUSION: NM is highly active against both gram-positive and gram-negative flora. Side effects are minimal.