Personalization of therapy for patients with eosinophilic esophagitis.

INTRODUCTION: The rising global prevalence of eosinophilic esophagitis (EoE) has made it a major topic of interest in both Clinical Immunology and Gastroenterology. Despite advances in understanding its physiopathology, optimal long-term management remains challenging due to disease heterogeneity and variable treatment responses. An integrated, patient-centered approach can be valuable in clinical practice, improving outcomes by tailoring treatment strategies to individual patient needs.

AREAS COVERED: This review explores the current therapeutic options of EoE, including proton pump inhibitors (PPIs), topical corticosteroids, elimination diets, and biologic agents, focusing on treatment efficacy, limitations, and patient-centered factors such as quality of life, treatment adherence, and comorbid atopic conditions. The article also examines recent guidelines and the rationale behind personalized therapy approaches. A comprehensive review of the current literature on personalized therapy for EoE has been conducted, highlighting recent developments in treatment strategies and individualized patient care approaches.

EXPERT OPINION: There is no one-size-fits-all therapeutic strategy for EoE. Given the complexity of patient profiles, including immunologic phenotypes, psychological attitudes, and socioeconomic factors, therapeutic choices must be personalized. Shared decision-making is essential to align treatment plans with patient values and improve both clinical outcomes and long-term adherence.