Combined Use of Aqueous Extracts and Polysaccharides from Angelica sinensis and Platycladus orientalis Treats Androgenetic Alopecia.

Androgenetic alopecia (AGA) is a widely prevalent condition that significantly impacts both physical well-being and psychological health. Conventional treatments are often accompanied by considerable side effects and demonstrate variable efficacy. This study explores the therapeutic potential of polysaccharides derived from Angelica sinensis (ASP) and Platycladus orientalis (POP), alongside their respective aqueous extracts, employing a dual approach that combines oral administration of polysaccharides with topical application. Notably, these polysaccharides and their aqueous extracts effectively attenuate follicular miniaturization and chronic inflammation, while simultaneously promoting the expression of CD31 and Ki67 proteins, thereby enhancing angiogenesis and follicular development. Furthermore, they reactivate the Wnt/β-catenin signaling pathway and inhibit androgen receptors (AR), resulting in a significant stimulation of hair regrowth. Cumulatively, the polysaccharides and their aqueous extracts indicate a promising approach for mitigating hair loss and inflammation linked to AGA, offering preliminary evidence for a novel therapeutic intervention in AGA that warrants further investigation.