Phytochemicals for Hair Health Targeting Growth Signaling Molecules in Hair Follicular Stem Cells: A New Strategy for Hair Growth.

Hair loss is a global concern, driving substantial public interest in effective therapeutic solutions. Beyond its protective physiological functions, hair plays a pivotal role in social and non-verbal communication, which can be profoundly disrupted by hair loss. While conventional pharmacological treatments are commonly employed, their use is often limited by the risk of adverse effects. To address this limitation, we propose the exploration of phytochemicals derived from natural sources as safer and potentially effective alternatives for hair loss prevention. Many natural compounds have shown the capacity to activate key signaling pathways involved in hair growth, offering promising avenues for innovation in the hair industry. This study explores the biological mechanisms underlying hair development, morphogenesis, and regeneration, with a particular focus on the Wnt/β-catenin, Sonic hedgehog (Shh), and Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathways, which are critical to hair growth. Furthermore, we provide a comprehensive compilation of natural materials known to promote hair growth and their associated phytochemicals. This repository serves as a foundation for identifying and developing novel agents to enhance hair regeneration. Our review highlights the need for continued research into identifying and refining safe, naturally derived candidates for the prevention and treatment of hair loss, thereby addressing a pressing unmet medical and cosmetic need.