Approach to Secretory Carcinoma of the Minor Salivary Glands of the Buccal Mucosa: A Case Report With a Review of the Literature.

Secretory carcinoma (SC) is a rare, low-grade malignant neoplasm of the salivary glands, most commonly arising in the parotid gland. Involvement of the minor salivary glands of the buccal mucosa is exceedingly rare, with only a handful of cases reported in the literature. A 30-year-old female presented with a one-year history of a swelling over the left cheek. On clinical examination, a 2 × 2 cm, lobulated, cystic swelling was identified in the left buccal mucosa. Fine-needle aspiration of the swelling showed predominantly eosinophilic material with occasional scattered cells. The lesion was surgically excised and submitted for histopathological examination. Gross examination revealed a gray-brown, soft-tissue mass measuring 2.5 × 2 × 1 cm. On serial sectioning, a well-circumscribed cystic, gray-white lesion measuring 1 cm in diameter was identified. Histopathological examination of the lesion showed features consistent with SC. The tumor cells were positive for GATA3, mammaglobin, S100, and CK7. The postoperative positron emission tomography-computed tomography revealed no tumor deposit, and the patient remained free of local recurrence during the six-month follow-up period.