The Laryngoscope · 2025
Increased Risk of Cholesteatoma in Individuals With Alpha-1 Antitrypsin Deficiency: A Cohort Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ali Abdulla, Ravn Helene Andresen, Dahl Morten, Djurhuus Bjarki Ditlev
Аннотация
OBJECTIVE: To estimate the risk of cholesteatoma in patients with alpha-1 antitrypsin deficiency (AATD) compared to the general population using time-to-event analysis.
METHODS: We conducted a nationwide nested cohort study identifying all patients with AATD in Denmark and subsequently matching each case with up to 10 controls based on age, sex, and municipality. Hazard ratios (HR) of cholesteatoma by AATD were calculated using Cox regression analysis adjusted for age and sex.
RESULTS: The study identified 2702 individuals with AATD and 26,750 control subjects. Individuals with AATD versus controls had a HR for cholesteatoma surgery of 3.62 (95% CI: 1.93-6.80) and a HR for non-cholesteatoma surgery of 1.40 (1.04-1.89).
CONCLUSION: Individuals with AATD had a 3.6-fold increased risk of cholesteatoma surgery compared with matched controls without AATD. The data support that AATD contributes to pathophysiological processes underlying the development of cholesteatoma.
METHODS: We conducted a nationwide nested cohort study identifying all patients with AATD in Denmark and subsequently matching each case with up to 10 controls based on age, sex, and municipality. Hazard ratios (HR) of cholesteatoma by AATD were calculated using Cox regression analysis adjusted for age and sex.
RESULTS: The study identified 2702 individuals with AATD and 26,750 control subjects. Individuals with AATD versus controls had a HR for cholesteatoma surgery of 3.62 (95% CI: 1.93-6.80) and a HR for non-cholesteatoma surgery of 1.40 (1.04-1.89).
CONCLUSION: Individuals with AATD had a 3.6-fold increased risk of cholesteatoma surgery compared with matched controls without AATD. The data support that AATD contributes to pathophysiological processes underlying the development of cholesteatoma.