Journal of surgical oncology · 2013
Prognostic value of total tumor volume in advanced-stage laryngeal and hypopharyngeal carcinoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yang Chan-Joo, Kim Dae-Yoon, Lee Jeong Hyun, Roh Jong-Lyel, Choi Seung-Ho, Nam Soon Yuhl, Kim Sang Yoon
Аннотация
BACKGROUND: To evaluate the prognostic value of total tumor volume (TTV) in patients with laryngeal and hypopharyngeal carcinomas.
METHODS: This study involved 182 patients with previously untreated advanced-stage squamous cell carcinoma of the larynx or hypopharynx. TTV were calculated from pretreatment contrast-enhanced computed tomography images. Univariate and multivariate analyses were used to identify factors associated with overall (OS), disease-specific (DSS), and disease-free survival (DFS).
RESULTS: At a median follow-up of 63 months (range, 24-139 months), the 5 year OS, DSS, and DFS rates were 60.2%, 73.1%, and 69.4%, respectively. Multivariate analyses showed that tumor site was an independent predictor of DSS (P = 0.03); Charlson comorbidity index for OS (P = 0.001); second primary cancer for OS (P = 0.008) and DFS (P = 0.001); and vocal fold paralysis for DSS (P = 0.014) and DFS (P = 0.033). Extension to the tongue base was an independent predictor of OS (P = 0.007), DSS (P < 0.001), and DFS (P = 0.017), and TTV ≥8.38 ml was an independent predictor of all three survivals (P < 0.001 each).
CONCLUSION: Radiologically determined TTV is prognostic of survival in patients with advanced-stage laryngeal and hypopharyngeal carcinoma.
METHODS: This study involved 182 patients with previously untreated advanced-stage squamous cell carcinoma of the larynx or hypopharynx. TTV were calculated from pretreatment contrast-enhanced computed tomography images. Univariate and multivariate analyses were used to identify factors associated with overall (OS), disease-specific (DSS), and disease-free survival (DFS).
RESULTS: At a median follow-up of 63 months (range, 24-139 months), the 5 year OS, DSS, and DFS rates were 60.2%, 73.1%, and 69.4%, respectively. Multivariate analyses showed that tumor site was an independent predictor of DSS (P = 0.03); Charlson comorbidity index for OS (P = 0.001); second primary cancer for OS (P = 0.008) and DFS (P = 0.001); and vocal fold paralysis for DSS (P = 0.014) and DFS (P = 0.033). Extension to the tongue base was an independent predictor of OS (P = 0.007), DSS (P < 0.001), and DFS (P = 0.017), and TTV ≥8.38 ml was an independent predictor of all three survivals (P < 0.001 each).
CONCLUSION: Radiologically determined TTV is prognostic of survival in patients with advanced-stage laryngeal and hypopharyngeal carcinoma.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAnalysis of VarianceCarcinoma, Squamous CellContrast MediaDisease-Free SurvivalFemaleFollow-Up StudiesHumansHypopharyngeal NeoplasmsKaplan-Meier EstimateLaryngeal NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsTomography, X-Ray ComputedTreatment OutcomeTumor BurdenVocal Cord Paralysis