The Journal of laryngology and otology · 2024
Parathyroid carcinoma: a tertiary centre's experience over 15 years.
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Wong Jeremy, Addison Alfred, Nassif Ramez
Аннотация
OBJECTIVES: The aim of this research is to determine the rate of recurrence, metastasis and survival outcomes of patients diagnosed with and treated for parathyroid carcinoma.
METHODS: This research is a retrospective chart review for patients diagnosed with parathyroid carcinomas between 1 January 2007 and 31 December 2022 in a UK tertiary centre.
RESULTS: Fourteen patients were identified, all of whom received surgery following their diagnosis. On presentation, all patients (100 per cent) were hypercalcaemic, with two patients (14 per cent) having metastatic lesions. There was a single case (7 per cent) of loco-regional recurrence following surgery. Six patients passed away after a median follow up of 2.5 years, four due to causes related to parathyroid carcinoma.
CONCLUSION: Surgical excision remains the mainstay of treatment, but this can only be undertaken after the patient has been medically stabilised. Mortality in this group of patients generally arose from the effects of hypercalcaemia. Metastasis and recurrence from our cohort were rare, but long-term follow up with monitoring of calcium and parathyroid hormone levels remain keys.
METHODS: This research is a retrospective chart review for patients diagnosed with parathyroid carcinomas between 1 January 2007 and 31 December 2022 in a UK tertiary centre.
RESULTS: Fourteen patients were identified, all of whom received surgery following their diagnosis. On presentation, all patients (100 per cent) were hypercalcaemic, with two patients (14 per cent) having metastatic lesions. There was a single case (7 per cent) of loco-regional recurrence following surgery. Six patients passed away after a median follow up of 2.5 years, four due to causes related to parathyroid carcinoma.
CONCLUSION: Surgical excision remains the mainstay of treatment, but this can only be undertaken after the patient has been medically stabilised. Mortality in this group of patients generally arose from the effects of hypercalcaemia. Metastasis and recurrence from our cohort were rare, but long-term follow up with monitoring of calcium and parathyroid hormone levels remain keys.