Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
Narcolepsy and risk of traumatic injury: a population-based matched cohort study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zheng Yunlong, Fukasawa Toshiki, Masuda Soichiro, Takeuchi Masato, Kawakami Koji
Аннотация
STUDY OBJECTIVES: We evaluated the risk of traumatic injury in patients with narcolepsy compared to the general population.
METHODS: We conducted a population-based matched cohort study using a Japanese health insurance claims database. For each patient with narcolepsy, up to 5 individuals from the general population without narcolepsy were matched by variables such as sex, age, and cohort entry month. The primary outcome was traumatic injury, and the secondary outcome was fracture. The study population was followed for up to 5 years from the cohort entry date. We estimated crude incidence rates, adjusted incidence rate differences, adjusted hazard ratios, and their 95% confidence intervals (CIs) for study outcomes using crude and multivariable Poisson and Cox regression models.
RESULTS: We included 2,451 patients with narcolepsy (mean age, 30.3 years; male, 58.0%) and 10,591 matched individuals (mean age, 30.6 years; male, 58.4%). Crude incidence rate of traumatic injury was 11.4 per 100 person-years for patients with narcolepsy compared with 6.2 per 100 person-years for matched individuals (adjusted incidence rate difference, 6.2 excess events per 100 person-years [95% CI, 4.9-7.4]; adjusted hazard ratio, 1.8 [95% CI, 1.5-2.2]). Crude incidence rate of fracture was 2.3 per 100 person-years for patients with narcolepsy compared with 1.3 per 100 person-years for matched individuals (adjusted incidence rate difference, 1.2 excess events per 100 person-years [95% CI, 0.7-1.7]; adjusted hazard ratio, 1.7 [95% CI, 1.4-2.1]).
CONCLUSIONS: Narcolepsy was associated with increased risk of traumatic injury. For patients with narcolepsy, optimized approaches to injury prevention should be considered.
CITATION: Zheng Y, Fukasawa T, Masuda S, Takeuchi M, Kawakami K. Narcolepsy and risk of traumatic injury: a population-based matched cohort study. J Clin Sleep Med. 2024;20(10):1657-1662.
METHODS: We conducted a population-based matched cohort study using a Japanese health insurance claims database. For each patient with narcolepsy, up to 5 individuals from the general population without narcolepsy were matched by variables such as sex, age, and cohort entry month. The primary outcome was traumatic injury, and the secondary outcome was fracture. The study population was followed for up to 5 years from the cohort entry date. We estimated crude incidence rates, adjusted incidence rate differences, adjusted hazard ratios, and their 95% confidence intervals (CIs) for study outcomes using crude and multivariable Poisson and Cox regression models.
RESULTS: We included 2,451 patients with narcolepsy (mean age, 30.3 years; male, 58.0%) and 10,591 matched individuals (mean age, 30.6 years; male, 58.4%). Crude incidence rate of traumatic injury was 11.4 per 100 person-years for patients with narcolepsy compared with 6.2 per 100 person-years for matched individuals (adjusted incidence rate difference, 6.2 excess events per 100 person-years [95% CI, 4.9-7.4]; adjusted hazard ratio, 1.8 [95% CI, 1.5-2.2]). Crude incidence rate of fracture was 2.3 per 100 person-years for patients with narcolepsy compared with 1.3 per 100 person-years for matched individuals (adjusted incidence rate difference, 1.2 excess events per 100 person-years [95% CI, 0.7-1.7]; adjusted hazard ratio, 1.7 [95% CI, 1.4-2.1]).
CONCLUSIONS: Narcolepsy was associated with increased risk of traumatic injury. For patients with narcolepsy, optimized approaches to injury prevention should be considered.
CITATION: Zheng Y, Fukasawa T, Masuda S, Takeuchi M, Kawakami K. Narcolepsy and risk of traumatic injury: a population-based matched cohort study. J Clin Sleep Med. 2024;20(10):1657-1662.