Frontiers in medicine · 2021
Case Report: Management of Malignancy-Exacerbated Pemphigus Vulgaris During COVID-19 Pandemic.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Corrà Alberto, Cammelli Francesca, Quintarelli Lavinia, Barbato Giuseppe, Le Rose Ornella, Salemme Adele, Di Zenzo Giovanni, Coratti Francesco, Verdelli Alice, Aimo Cristina, Mariotti Elena Biancamaria, Bianchi Beatrice, Cianchi Fabio, Caproni Marzia
Аннотация
Pemphigus vulgaris is an intraepidermal autoimmune mucocutaneous blistering disease whose etiopathogenesis includes various trigger factors, i.e., drugs and malignancies. We present a case of malignancy-exacerbated pemphigus vulgaris which required a careful diagnostic process in order to rule out paraneoplastic pemphigus, along with the challenges posed by the need of treating both cutaneous and oncologic diseases. Possible post-operative complications post-poned the start of first-line immunosuppressive treatment of pemphigus. Moreover, the infective risks had to be minimized during the peak of the COVID-19 pandemic in Italy. Intravenous immunoglobulins were chosen as "bridge" therapy before the tumor surgical excision, followed by rituximab in post-operative phase.