Journal of veterinary internal medicine · 2025
Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kamr Ahmed M, Bartish Celine, Summers Jamie, Horton Julia, Hostnik Laura D, Orr Kindra, Browne Nimet, Dembek Katarzyna A, Saliba Caroline, Gomez Diego E, Toribio Ramiro E
Аннотация
BACKGROUND: Information about the association of antimicrobial peptides with hypovitaminosis D in hospitalized foals is lacking.
HYPOTHESIS/OBJECTIVES: We aimed to longitudinally determine the association of serum concentrations of vitamin D metabolites, vitamin D binding protein (DBP), and parathyroid hormone (PTH) with antimicrobial peptides (β-defensin-1 and cathelicidin-1) and the mRNA expression of the vitamin D receptor (VDR), 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1), toll-like receptor-4 (TLR-4), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), disease severity, and mortality in hospitalized foals. We hypothesized that hypovitaminosis D would be associated with decreased serum concentrations of antimicrobial peptides, disease severity, and mortality in hospitalized foals.
ANIMALS: One hundred nine foals ≤ 72 h of age divided into hospitalized (n = 83; 60 septic, 23 sick nonseptic [SNS]) and healthy (n = 26) foals.
METHODS: Blood samples were collected on admission (0), and 24, 48, and 72 h after admission from healthy and hospitalized foals. Data were analyzed by repeated measure methods.
RESULTS: Serum 25(OH)D, 1,25(OH)2D, DBP, β-defensin-1, and cathlicidin-1 concentrations were significantly lower, whereas PTH concentrations were higher in hospitalized compared to healthy foals at different times during hospitalization (p < 0.05). Septic foals had lower VDR and CYP27B1, but higher TLR-4, TNF-α, and IL-1β mRNA expression than in healthy foals (p < 0.05). Decreased serum 25(OH)D, β-defensin-1, and cathelicidin-1, and high PTH concentrations were associated with higher odds of death in hospitalized foals (p < 0.05).
CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased vitamin D metabolite concentrations and decreased antimicrobial peptide concentrations suggest that vitamin D has important immunomodulatory functions in newborn foals.
HYPOTHESIS/OBJECTIVES: We aimed to longitudinally determine the association of serum concentrations of vitamin D metabolites, vitamin D binding protein (DBP), and parathyroid hormone (PTH) with antimicrobial peptides (β-defensin-1 and cathelicidin-1) and the mRNA expression of the vitamin D receptor (VDR), 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1), toll-like receptor-4 (TLR-4), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), disease severity, and mortality in hospitalized foals. We hypothesized that hypovitaminosis D would be associated with decreased serum concentrations of antimicrobial peptides, disease severity, and mortality in hospitalized foals.
ANIMALS: One hundred nine foals ≤ 72 h of age divided into hospitalized (n = 83; 60 septic, 23 sick nonseptic [SNS]) and healthy (n = 26) foals.
METHODS: Blood samples were collected on admission (0), and 24, 48, and 72 h after admission from healthy and hospitalized foals. Data were analyzed by repeated measure methods.
RESULTS: Serum 25(OH)D, 1,25(OH)2D, DBP, β-defensin-1, and cathlicidin-1 concentrations were significantly lower, whereas PTH concentrations were higher in hospitalized compared to healthy foals at different times during hospitalization (p < 0.05). Septic foals had lower VDR and CYP27B1, but higher TLR-4, TNF-α, and IL-1β mRNA expression than in healthy foals (p < 0.05). Decreased serum 25(OH)D, β-defensin-1, and cathelicidin-1, and high PTH concentrations were associated with higher odds of death in hospitalized foals (p < 0.05).
CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased vitamin D metabolite concentrations and decreased antimicrobial peptide concentrations suggest that vitamin D has important immunomodulatory functions in newborn foals.