Blood · 2013
Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia.
Клиническое исследование II фазыСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Strati Paolo, Keating Michael J, Wierda William G, Badoux Xavier C, Calin Steliana, Reuben James M, O'Brien Susan, Kornblau Steven M, Kantarjian Hagop M, Gao Hui, Ferrajoli Alessandra
Аннотация
We evaluated long-term outcomes of 60 patients with chronic lymphocytic leukemia treated with an initial therapy of lenalidomide. At a median follow-up of 4 years, time-to-treatment failure has not been reached and overall survival is 82%. Thirty-five (58%) patients had a response lasting >36 months (long-term responders [LTRs]). Best LTR responses consisted of 25 (71%) complete remissions and 10 (29%) partial remissions. In addition to clinical responses, an increase in IgA, IgG, and IgM levels of >50% from baseline was reported in 61%, 45%, and 42% of LTRs. Normalization in the percentage of CD4+ and CD8+ cells and T-cell numbers was observed in 48%, 71% and 99% of LTRs. Compared with other patients in the study, LTRs had lower baseline plasma levels of β-2-microglobulin, were more likely to have trisomy 12, and less likely to have deletion 17p.