Journal of cutaneous pathology · 2017
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp.
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Sar-Pomian Marta, Czuwara Joanna, Rudnicka Lidia, Olszewska Malgorzata
Аннотация
BACKGROUND: Intraepidermal acantholysis is a characteristic histopathological feature of pemphigus. The histopathology of scalp biopsies in pemphigus has not been widely discussed in the literature, although the scalp is commonly involved in pemphigus.
METHODS: A total of 32 consecutive patients with scalp involvement (17 with pemphigus vulgaris [PV] and 15 with pemphigus foliaceus [PF]) were enrolled into the study. The histopathological examination of scalp biopsies was performed in all patients. Tissue specimens were stained with hematoxylin and eosin.
RESULTS: Acantholysis extended down the entire length of the outer root sheath of the hair follicle in 12 of 17 (70.6%) patients with PV. Follicular acantholysis in PF was restricted to the infundibulum and occurred in 12 of 15 (80.0%) patients. Acantholysis in the vellus hair follicles was observed in 12 of 17 (70.6%) and 9 of 15 (60.0%) cases, respectively. The miniaturization of sebaceous glands was seen in 14 of 17 (82.4%) and 12 of 15 (80.0%) patients, respectively.
CONCLUSIONS: Follicular acantholysis is a common histopathological feature of pemphigus. It may serve as a clue to the diagnosis of pemphigus subtypes, as PV and PF differ in the depth of follicular acantholysis. The miniaturization of sebaceous glands is a common histopathological feature observed in scalp specimens of patients with pemphigus.
METHODS: A total of 32 consecutive patients with scalp involvement (17 with pemphigus vulgaris [PV] and 15 with pemphigus foliaceus [PF]) were enrolled into the study. The histopathological examination of scalp biopsies was performed in all patients. Tissue specimens were stained with hematoxylin and eosin.
RESULTS: Acantholysis extended down the entire length of the outer root sheath of the hair follicle in 12 of 17 (70.6%) patients with PV. Follicular acantholysis in PF was restricted to the infundibulum and occurred in 12 of 15 (80.0%) patients. Acantholysis in the vellus hair follicles was observed in 12 of 17 (70.6%) and 9 of 15 (60.0%) cases, respectively. The miniaturization of sebaceous glands was seen in 14 of 17 (82.4%) and 12 of 15 (80.0%) patients, respectively.
CONCLUSIONS: Follicular acantholysis is a common histopathological feature of pemphigus. It may serve as a clue to the diagnosis of pemphigus subtypes, as PV and PF differ in the depth of follicular acantholysis. The miniaturization of sebaceous glands is a common histopathological feature observed in scalp specimens of patients with pemphigus.