Head & neck · 2016
Salvage transoral laser microsurgery for recurrent glottic carcinoma after primary laser-assisted treatment: Analysis of prognostic factors.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Lucioni Marco, Bertolin Andy, Lionello Marco, Giacomelli Luciano, Rizzotto Giuseppe, Marioni Gino
Аннотация
BACKGROUND: Treatment for local glottic cancer recurrences after primary transoral laser microsurgery (TLM) has not been standardized.
METHODS: In 33 consecutive cases of salvage TLM after laser surgery for early glottic carcinoma failed, we retrospectively considered the potential clinicopathological prognostic factors in univariate statistical setting.
RESULTS: Patient age <65 years and pathological involvement of the deep margins were associated with a higher second recurrence rate and shorter disease-free survival.
CONCLUSION: The age of the patient and the pathological status of surgical margins after salvage TLM could be useful for planning a closer endoscopic/radiological follow-up in selected patients at high risk of recurrence. Other appropriately designed studies are needed to see if an open surgical approach should be considered for younger patients (<65 years old) with recurrent glottic carcinoma after primary TLM. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1043-1049, 2016.
METHODS: In 33 consecutive cases of salvage TLM after laser surgery for early glottic carcinoma failed, we retrospectively considered the potential clinicopathological prognostic factors in univariate statistical setting.
RESULTS: Patient age <65 years and pathological involvement of the deep margins were associated with a higher second recurrence rate and shorter disease-free survival.
CONCLUSION: The age of the patient and the pathological status of surgical margins after salvage TLM could be useful for planning a closer endoscopic/radiological follow-up in selected patients at high risk of recurrence. Other appropriately designed studies are needed to see if an open surgical approach should be considered for younger patients (<65 years old) with recurrent glottic carcinoma after primary TLM. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1043-1049, 2016.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAnalysis of VarianceCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleGlottisHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaser TherapyMaleMicrosurgeryMiddle AgedNatural Orifice Endoscopic SurgeryNeoplasm Recurrence, LocalReoperationRetrospective StudiesRisk AssessmentSalvage TherapyStatistics, NonparametricSurvival AnalysisTreatment Outcome