[Changes in the kallikrein-kinin system and lipid peroxidation in patients with diffuse peritonitis, complicated by adult respiratory distress syndrome].

The authors present results of their investigation of the state of kallikrein-kinin system (KKS) and lipid peroxidation (LP) in blood of 22 patients operated upon for acute diffuse peritonitis as a complication of different surgical diseases. In 8 patients who later died the respiratory distress-syndrome of adults (RDSA) developed at the early postoperative period. Activation of KKS and LP were observed in all the patients both in the venous and arterial blood, but it was more intensive in patients with RDSA. In the same group of patients the level of the metabolites under study was higher in the arterial than in the venous blood, which suggests a disturbances of the metabolic function of the lung. The results of the investigation allow a conclusion that antiprotease drugs should be included in the complex treatment of RDSA.