Journal of magnetic resonance imaging : JMRI · 2022
Multiparametric Magnetic Resonance Imaging for Assessing Thymic Epithelial Tumors: Correlation With Pathological Subtypes and Clinical Stages.
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Shen Jie, Zhang Wei, Zhu Jia-Jia, Xue Lei, Yuan Mei, Xu Hai, Xu Xiao-Quan, Yu Tong-Fu, Wu Fei-Yun
Аннотация
BACKGROUND: World Health Organization classification and Masaoka-Koga stage are widely used for thymic epithelial tumors (TETs). Reduced field-of-view (rFOV) diffusion-weighed imaging (DWI) proved to improve the image quality. Dynamic contrast-enhanced (DCE) MRI was commonly used in evaluating tumors.
PURPOSE: To investigate the value of multiparametric MRI in evaluating TETs.
STUDY TYPE: Retrospective.
SUBJECTS: Eighty-seven participants including 38 low risk (52.08 ± 14.19 years), 30 high risk (52.40 ± 11.35 years), and 19 thymic carcinoma patients (59.76 ± 10.78 years).
FIELD STRENGTH/SEQUENCE: A 3 T, turbo spin echo imaging, echo planar imaging, volumetric interpolated breath-hold examination with radial acquisition trajectory.
ASSESSMENT: DCE-MRI and apparent diffusion coefficient (ADC) variables were compared. Diagnostic performances of single significant factor and combined model were compared.
STATISTICAL TESTS: Parameters were compared using one-way ANOVA or independent-samples t test. Logistic regression was employed to investigate the combined model. Receiver operating curves (ROC) and DeLong's test were used to compare the diagnostic efficiency.
RESULTS: ADC, Ktrans , and kep values were significantly different among low-risk, high-risk and carcinoma group (ADC, 1.279 ± 0.345 × 10-3 mm2 /sec, 0.978 ± 0.260 × 10-3 mm2 /sec, 0.661 ± 0.134 × 10-3 mm2 /sec; Ktrans 0.167 ± 0.071 min-1 , 0.254 ± 0.136 min-1 , 0.393 ± 0.110 min-1 ; kep 0.345 ± 0.113 min-1 , 0.560 ± 0.269 min-1 , 0.872 ± 0.149 min-1 ). They were significantly different for early stage and advanced stage (ADC, 1.270 ± 0.356 × 10-3 mm2 /sec vs. 0.845 ± 0.251 × 10-3 mm2 /sec; Ktrans 0.179 ± 0.092 min-1 vs. 0.304 ± 0.142 min-1 ; kep 0.370 ± 0.181 min-1 vs. 0.674 ± 0.362 min-1 ). The combination of them had highest diagnostic efficiency for WHO classification (AUC, 0.925; sensitivity, 83.7%; specificity, 89.5%), clinical stage (AUC, 0.879; sensitivity, 80.9%; specificity, 82.5%).
DATA CONCLUSION: Multiparametric MRI model may be useful for discriminating WHO classification and clinical stage of TETs.
EVIDENCE LEVEL: 4 TECHNICAL EFFICIENCY: Stage 2.
PURPOSE: To investigate the value of multiparametric MRI in evaluating TETs.
STUDY TYPE: Retrospective.
SUBJECTS: Eighty-seven participants including 38 low risk (52.08 ± 14.19 years), 30 high risk (52.40 ± 11.35 years), and 19 thymic carcinoma patients (59.76 ± 10.78 years).
FIELD STRENGTH/SEQUENCE: A 3 T, turbo spin echo imaging, echo planar imaging, volumetric interpolated breath-hold examination with radial acquisition trajectory.
ASSESSMENT: DCE-MRI and apparent diffusion coefficient (ADC) variables were compared. Diagnostic performances of single significant factor and combined model were compared.
STATISTICAL TESTS: Parameters were compared using one-way ANOVA or independent-samples t test. Logistic regression was employed to investigate the combined model. Receiver operating curves (ROC) and DeLong's test were used to compare the diagnostic efficiency.
RESULTS: ADC, Ktrans , and kep values were significantly different among low-risk, high-risk and carcinoma group (ADC, 1.279 ± 0.345 × 10-3 mm2 /sec, 0.978 ± 0.260 × 10-3 mm2 /sec, 0.661 ± 0.134 × 10-3 mm2 /sec; Ktrans 0.167 ± 0.071 min-1 , 0.254 ± 0.136 min-1 , 0.393 ± 0.110 min-1 ; kep 0.345 ± 0.113 min-1 , 0.560 ± 0.269 min-1 , 0.872 ± 0.149 min-1 ). They were significantly different for early stage and advanced stage (ADC, 1.270 ± 0.356 × 10-3 mm2 /sec vs. 0.845 ± 0.251 × 10-3 mm2 /sec; Ktrans 0.179 ± 0.092 min-1 vs. 0.304 ± 0.142 min-1 ; kep 0.370 ± 0.181 min-1 vs. 0.674 ± 0.362 min-1 ). The combination of them had highest diagnostic efficiency for WHO classification (AUC, 0.925; sensitivity, 83.7%; specificity, 89.5%), clinical stage (AUC, 0.879; sensitivity, 80.9%; specificity, 82.5%).
DATA CONCLUSION: Multiparametric MRI model may be useful for discriminating WHO classification and clinical stage of TETs.
EVIDENCE LEVEL: 4 TECHNICAL EFFICIENCY: Stage 2.