Anticancer research · 2020
The Contribution of MMP-9 Genotypes to Pterygium in Taiwan.
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Tsai Chong-Bin, Hsia Ning-Yi, Wang Zhi-Hong, Yang Jai-Sing, Hsu Yuan-Man, Wang Yun-Chi, Chang Wen-Shin, Bau DA-Tian, Yin Mei-Chin, Tsai Chia-Wen
Аннотация
BACKGROUND/AIM: The studies about the roles of matrix metalloproteinases (MMPs) in pterygium diagnosis and/or prognosis are mainly based on their mRNA and protein levels, while the genomic roles of MMPs are seldom examined. The aim of this study was to investigate the contribution of MMP-9 genotypes to pterygium risk.
MATERIALS AND METHODS: MMP-9 rs3918242 was genotyped in 134 pterygium cases and 268 controls via polymerase chain reaction-restriction fragment length polymorphism.
RESULTS: The rs3918242 genotype percentages of CC, CT, and TT were 73.1, 25.4 and 1.5% among cases and 74.6, 23.1 and 2.3% among controls (p trend=0.7928). The odds ratios after adjusting for age and gender for CT and TT genotypes at rs3918242 were 1.08 and 0.92 (95%CI=0.66-1.73 and 0.45-2.89, p=0.6478 and 0.6389), respectively. In addition, allelic frequency analysis showed no significant difference in the distribution of allelic frequencies between the pterygium and control groups.
CONCLUSION: The genotypes at MMP-9 rs3918242 play a minor role in determining personal susceptibility to pterygium.
MATERIALS AND METHODS: MMP-9 rs3918242 was genotyped in 134 pterygium cases and 268 controls via polymerase chain reaction-restriction fragment length polymorphism.
RESULTS: The rs3918242 genotype percentages of CC, CT, and TT were 73.1, 25.4 and 1.5% among cases and 74.6, 23.1 and 2.3% among controls (p trend=0.7928). The odds ratios after adjusting for age and gender for CT and TT genotypes at rs3918242 were 1.08 and 0.92 (95%CI=0.66-1.73 and 0.45-2.89, p=0.6478 and 0.6389), respectively. In addition, allelic frequency analysis showed no significant difference in the distribution of allelic frequencies between the pterygium and control groups.
CONCLUSION: The genotypes at MMP-9 rs3918242 play a minor role in determining personal susceptibility to pterygium.