The Australian and New Zealand journal of psychiatry · 1996
An XXYY male with schizophrenia.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Lee J W
Аннотация
OBJECTIVE: A case of XXYY associated with schizophrenia is presented.
CLINICAL PICTURE: A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression.
TREATMENT AND OUTCOME: A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy.
CONCLUSIONS: This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.
CLINICAL PICTURE: A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression.
TREATMENT AND OUTCOME: A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy.
CONCLUSIONS: This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.