[Side effects of psychopharmacotherapy in patients with schizophrenia proceeding against a background of organic cerebral insufficiency].

Analyzed were 1999 courses of treatment in 212 patients with paroxysmal and paranoid schizophrenia. Twelve groups of side-effects were defined according to syndromal and structural principles. Compared to the uncomplicated schizophrenic patients, the ones with organic cerebral insufficiency had higher sensitivity to psychopharmacologic drug therapy. The number of untoward effects per one course of treatment in organically deficient patients was 1.5 times higher than that of the control group. It was also shown that cerebral organic insufficiency promoted the long-lasting and chronic extrapyramidal disorders. It also increased the rate of akathisia, akinetic-rigid syndrome, hyperkineses, fever, epileptiform paroxysms, circulatory-autonomic disorders. Side-effects were closely related to the nature of drug therapy.