Journal of the American Academy of Dermatology · 2014
Frontal fibrosing alopecia: a multicenter review of 355 patients.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Vañó-Galván Sergio, Molina-Ruiz Ana M, Serrano-Falcón Cristina, Arias-Santiago Salvador, Rodrigues-Barata Ana R, Garnacho-Saucedo Gloria, Martorell-Calatayud Antonio, Fernández-Crehuet Pablo, Grimalt Ramón, Aranegui Beatriz, Grillo Emiliano, Diaz-Ley Blanca, Salido Rafael, Pérez-Gala Sivia, Serrano Salvio, Moreno Jose Carlos, Jaén Pedro, Camacho Francisco M
Аннотация
BACKGROUND: To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment.
OBJECTIVE: We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA.
METHODS: This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline.
RESULTS: In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%).
LIMITATIONS: The retrospective design is a limitation.
CONCLUSIONS: Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
OBJECTIVE: We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA.
METHODS: This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline.
RESULTS: In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%).
LIMITATIONS: The retrospective design is a limitation.
CONCLUSIONS: Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
Предметные рубрики MeSH
AdultAge DistributionAgedAged, 80 and overAlopeciaAzasteroidsBiopsy, NeedleCohort StudiesDutasterideFemaleFibrosisFinasterideForeheadHumansImmunohistochemistryMaleMiddle AgedMultivariate AnalysisPostmenopauseRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionSpainTreatment OutcomeYoung Adult