Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 1999
[Study on G487A mutation of the glucose-6-phosphate dehydrogenase gene].
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Jiang W, Du C, Chen L
Аннотация
OBJECTIVE: In order to reveal the molecular evolution and ethnic origin and immigration, on the basis of G6PD G487A mutation, and estimate the incidence of the mutation in Bai, Dai, and Han people in Yunnan and Guangxi.
METHOD: G6PD deficient individuals were studied by using PCR-RE, PCR-SSCP and DNA sequencing.
RESULTS: The G487A mutation in Bai and Dai people was identified for the first time and its relative incidences were 6/66 and 1/52, respectively. The individuals of G6PD G487A mutation showed the features of G6PD clinic type III. No G487A was found in Han people in Guangxi(0/46).
CONCLUSION: The G6PD G487A mutation revealed in some ethnic groups of China implies that different national minorities of Chinese may be origined from a common ancestor.
METHOD: G6PD deficient individuals were studied by using PCR-RE, PCR-SSCP and DNA sequencing.
RESULTS: The G487A mutation in Bai and Dai people was identified for the first time and its relative incidences were 6/66 and 1/52, respectively. The individuals of G6PD G487A mutation showed the features of G6PD clinic type III. No G487A was found in Han people in Guangxi(0/46).
CONCLUSION: The G6PD G487A mutation revealed in some ethnic groups of China implies that different national minorities of Chinese may be origined from a common ancestor.