Neurosurgery · 2018
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Pathological Methods and Prognostic Factors in Vestibular Schwannomas.
СтатьяКлинические рекомендацииПоддержка исследования: вне правительства СШАСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Sughrue Michael E, Fung Kar-Ming, Van Gompel Jamie J, Peterson Jo Elle G, Olson Jeffrey J
Аннотация
TARGET POPULATION: Adults diagnosed with vestibular schwannomas.
QUESTION 1: What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 2: What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 3: Are there other light microscopic features that predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 4: Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 5: Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 6: Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.
QUESTION 1: What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 2: What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 3: Are there other light microscopic features that predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 4: Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 5: Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data.
QUESTION 6: Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas?
RECOMMENDATION: No recommendations can be made due to a lack of adequate data. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.