[Role of blood insulin in the etiology of dyslipoproteinemias and ischemic heart disease in males aged 20-69 years].

A random sample of males aged 20-69 years and living in one of the administrative districts of Moscow was studied. The total number of those enrolled was 1225, and they were studied for the incidence of dyslipoproteinemias and coronary heart disease (CHD) in relation to the level of glycemia, basal insulinemia, diabetes mellitus or impaired tolerance to glucose. It was shown that the effect of disorders of carbohydrate metabolism is largely determined by the level of insulinemia and is mediated through the development of dyslipoproteinemias. The prevalence of CHD without dyslipoproteinemias as well as in combination with arterial hypertension or an excessive body weight did not depend on the level of glycemia and baseline insulinemia or the presence of diabetes mellitus. Hyperinsulinemia was found to be associated with types of dyslipoproteinemias most unfavourable in terms of CHD development.