Effect of reduction of triacylglycerol level on fatty acid and glucose incorporation into human adipose tissue in type IV hyperlipoproteinaemia.

The fatty acid incorporation into adipose tissue (FIAT) and glucose incorporation into adipose tissue (GLIAT) have been measured in 11 patients suffering from Type IV hyperlipoproteinaemia during the hypertriglyceridaemic phase (HTG) and after normalization of triacylglycerol (TG) levels as a result of a diet which was adapted to the nutritional response of subjects. Results have been compared with those obtained in 10 reference subjects. During the HTG phase FIAT and GLIAT activities were significantly lower than in the case of reference subjects: FIAT (76.5 vs 185 nmol divided by 3/g adipose tissue/h, GLIAT (92.5 vs 208 nmol x2/g adipose tissue/h). After reduction of HTG, these activities increased in a significant way, FIAT (137.7 vs 76.5 nmol divided by 3/g/h) and GLIAT (160 vs 92.5 nmol X 2/g/h). These results agree with the hypothesis that the reduced incorporation of fatty acids and glucose into adipose tissue, measured in vitro, is partly due to the modification of the profile of lipoproteins and apoproteins related to hypertriglyceridaemia.