The Journal of dermatological treatment · 2025
Safety and efficacy of high-intensity macro-focused ultrasound for solar lentigo in Chinese patients: a prospective study.
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Pan Ruoxin, Gu Duoduo, Ye Qin, Meng Xiaoqi, Liu Tingwei, Lu Yan, Xu Yang
Аннотация
BACKGROUND: Solar lentigo (SL) is a skin disorder associated with photoaging. Studies suggest that high-intensity focused ultrasound can improve UV-induced hyperpigmentation and melasma.
OBJECTIVES: To evaluate the efficacy and safety of high-intensity macro-focused ultrasound (HI-MFU) for treating SL in Chinese.
METHODS: This is a prospective, single-center study. Twenty-one patients with SL on both cheeks underwent HI-MFU treatment. Follow-ups at baseline and 2, 4, 6, and 8 weeks post-treatment were conducted to assess improvements using clinical imaging, noninvasive skin assessments, and the Global Esthetic Improvement Scale.
RESULTS: The lesional and non-lesional areas showed an increase in L* values at all time points (p < 0.05). Transepidermal water loss values decreased on the left at 8 weeks (p < 0.001). Only two patients experienced transient mild pain and localized edema post-treatment. Two-photon microscopy revealed an uneven two-photon-excited fluorescence signal enhancement surrounding the nuclei of the stratum granulosum and stratum spinosum cells in the SL. At 8 weeks post-treatment, fluorescence signals in both areas were reduced compared to those at baseline.
CONCLUSIONS: HI-MFU effectively and safely treats SL and enhances skin tightness, lightness, and barrier function, suggesting its ultrasound-toning potential.
OBJECTIVES: To evaluate the efficacy and safety of high-intensity macro-focused ultrasound (HI-MFU) for treating SL in Chinese.
METHODS: This is a prospective, single-center study. Twenty-one patients with SL on both cheeks underwent HI-MFU treatment. Follow-ups at baseline and 2, 4, 6, and 8 weeks post-treatment were conducted to assess improvements using clinical imaging, noninvasive skin assessments, and the Global Esthetic Improvement Scale.
RESULTS: The lesional and non-lesional areas showed an increase in L* values at all time points (p < 0.05). Transepidermal water loss values decreased on the left at 8 weeks (p < 0.001). Only two patients experienced transient mild pain and localized edema post-treatment. Two-photon microscopy revealed an uneven two-photon-excited fluorescence signal enhancement surrounding the nuclei of the stratum granulosum and stratum spinosum cells in the SL. At 8 weeks post-treatment, fluorescence signals in both areas were reduced compared to those at baseline.
CONCLUSIONS: HI-MFU effectively and safely treats SL and enhances skin tightness, lightness, and barrier function, suggesting its ultrasound-toning potential.