Coagulation Dysfunction and Prognosis in Severe Fever With Thrombocytopenia Syndrome: A Comprehensive Analysis.

Severe Fever with Thrombocytopenia Syndrome (SFTS) is a zoonotic infectious disease with high mortality, in which coagulation dysfunction triggered by the virus serves as a critical factor in disease progression and patient death. This study comprehensively analyzed coagulation characteristics and the impact of concomitant Disseminated Intravascular Coagulation (DIC) on prognosis in 187 SFTS patients. Significant differences (p < 0.05) in coagulation parameters were observed among SFTS patients with varying disease severity and viral loads. The dynamic changes in coagulation parameters, especially activated partial thromboplastin time(APTT) and d-dimer (DD), differed significantly between the survival group and the death group. Prothrombin time(PT), International Normalized Ratio(INR), APTT, thrombin time(TT), and DD were identified as independent risk factors for death in SFTS patients. Furthermore, APTT ≥ 51.3 s (p = 0.001), TT ≥ 30.5 s (p = 0.023), and DD ≥ 2.39 µg/mL (p = 0.009) were shown to be effective predictors of patient mortality. Additionally, significant differences (p < 0.001) in admission coagulation parameters were found in SFTS patients complicated by DIC, among whom APTT was identified as an independent risk factor for death in this subgroup. Therefore, monitoring coagulation parameters aids in the early identification of high-risk patients, and intensive coagulation management may help improve patient prognosis.