Expert review of hematology · 2025
Subclinical myocardial dysfunction in essential thrombocythemia: role of global longitudinal strain.
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Demirkıran Aykut, Aydın Cihan, Orta Hüseyin, Uslu Nurullah, Öztürk Damla, Akpınar Seval, Alpsoy Şeref
Аннотация
BACKGROUND: The present study aimed to evaluate cardiac global longitudinal strain (GLS) in patients diagnosed with essential thrombocytosis (ET).
RESEARCH DESIGN AND METHODS: Patients diagnosed with ET were consecutively screened in the hematology department of our institution. Patients who underwent transthoracic echocardiography within 1 year of diagnosis were included in the study. A control group of healthy individuals matched for demographic characteristics was established. Second echocardiographic evaluation was performed during the follow-up period. The routine echocardiographic and strain parameters of both groups were compared.
RESULTS: A total of 92 participants were included, consisting of 60 patients with ET and 32 healthy volunteers. GLS values were reduced in the ET group compared to the control group (16.5 ± 2.4% vs. 22.5 ± 2.2%; p = 0.024). Among ET patients, those with GLS values ≤ 18% had a higher prevalence of the JAK2 mutation (81.1% vs. 21.7%; p < 0.001). In univariate logistic regression analysis, presence of the JAK2 mutation (OR: 4.6; 95% CI: 1.01-21; p = 0.04) was independently associated with reduced GLS.
CONCLUSIONS: ET may reduce GLS, especially in the presence of JAK2 mutation.
RESEARCH DESIGN AND METHODS: Patients diagnosed with ET were consecutively screened in the hematology department of our institution. Patients who underwent transthoracic echocardiography within 1 year of diagnosis were included in the study. A control group of healthy individuals matched for demographic characteristics was established. Second echocardiographic evaluation was performed during the follow-up period. The routine echocardiographic and strain parameters of both groups were compared.
RESULTS: A total of 92 participants were included, consisting of 60 patients with ET and 32 healthy volunteers. GLS values were reduced in the ET group compared to the control group (16.5 ± 2.4% vs. 22.5 ± 2.2%; p = 0.024). Among ET patients, those with GLS values ≤ 18% had a higher prevalence of the JAK2 mutation (81.1% vs. 21.7%; p < 0.001). In univariate logistic regression analysis, presence of the JAK2 mutation (OR: 4.6; 95% CI: 1.01-21; p = 0.04) was independently associated with reduced GLS.
CONCLUSIONS: ET may reduce GLS, especially in the presence of JAK2 mutation.