[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 1996
[A study on relationship between glutathione S-transferase mu gene deletion and senile cataract susceptibility].
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Pi J, Bai Y, Zheng Q
Аннотация
OBJECTIVE: To study the relationship between glutathione S-transferase mu (GST mu) gene deletion and senile cataract (SC) susceptibility.
METHOD: Polymerase chain reaction (PCR) method was used to investigate the rates of GST mu gene deletion in 59 cases with SC and 112 healthy controls.
RESULTS: The rate of GST mu gene deletion in cases with SC was 69.5% which was significantly higher than that of the controls, 50.9% (P < 0.05). An analysis stratified by smoking and nonsmoking showed that GST mu gene deletion rate in smoking subjects with SC was higher. Because of the small sample size of this study, although the rate of GST mu gene deletion in smoking subjects with SC has reached 72.4%, that is not significantly different from that of the controls statistically (P > 0.05).
CONCLUSION: SC correlates with GST mu gene deletion and GST mu gene deletion is one of the hereditary factors for susceptibility to SC.
METHOD: Polymerase chain reaction (PCR) method was used to investigate the rates of GST mu gene deletion in 59 cases with SC and 112 healthy controls.
RESULTS: The rate of GST mu gene deletion in cases with SC was 69.5% which was significantly higher than that of the controls, 50.9% (P < 0.05). An analysis stratified by smoking and nonsmoking showed that GST mu gene deletion rate in smoking subjects with SC was higher. Because of the small sample size of this study, although the rate of GST mu gene deletion in smoking subjects with SC has reached 72.4%, that is not significantly different from that of the controls statistically (P > 0.05).
CONCLUSION: SC correlates with GST mu gene deletion and GST mu gene deletion is one of the hereditary factors for susceptibility to SC.