Journal of biotechnology · 2012
Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production.
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Soares Siomar C, Trost Eva, Ramos Rommel T J, Carneiro Adriana R, Santos Anderson R, Pinto Anne C, Barbosa Eudes, Aburjaile Flávia, Ali Amjad, Diniz Carlos A A, Hassan Syed S, Fiaux Karina, Guimarães Luis C, Bakhtiar Syeda M, Pereira Ulisses, Almeida Sintia S, Abreu Vinícius A C, Rocha Flávia S, Dorella Fernanda A, Miyoshi Anderson, Silva Artur, Azevedo Vasco, Tauch Andreas
Аннотация
Corynebacterium pseudotuberculosis is the causative agent of several veterinary diseases in a broad range of economically important hosts, which can vary from caseous lymphadenitis in sheep and goats (biovar ovis) to ulcerative lymphangitis in cattle and horses (biovar equi). Existing vaccines against C. pseudotuberculosis are mainly intended for small ruminants and, even in these hosts, they still present remarkable limitations. In this study, we present the complete genome sequence of C. pseudotuberculosis biovar equi strain 258, isolated from a horse with ulcerative lymphangitis. The genome has a total size of 2,314,404 bp and contains 2088 predicted protein-coding regions. Using in silico analysis, eleven pathogenicity islands were detected in the genome sequence of C. pseudotuberculosis 258. The application of a reverse vaccinology strategy identified 49 putative antigenic proteins, which can be used as candidate vaccine targets in future works.