Saudi medical journal · 2025
The association between inflammatory bowel disease and ischemic heart disease: A retrospective cohort study.
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Mosli Mahmoud H, Alsulami Dima M, Alghamdi Yara K, Badahdah Abdullah S, Alhibshi Asmaa H, Alamri Thamer M, Alkhattabi Maan S, Alzahrani Khames T, Alsufyani Hadeel A, Saadah Omar I
Аннотация
OBJECTIVES: To evaluate the association between Inflammatory bowel disease (IBD) and Ischemic heart disease (IHD).
METHODS: A retrospective cohort analysis included patients with and without IBD seen at the outpatient gastroenterology clinic of a large tertiary care hospital between January 2015 and October 2022. The primary outcome was the association between IBD and IHD, and the secondary outcome was predictors of IHD in patients with IBD.
RESULTS: The study included 400 patients; 291 were IBD patients, and 109 had other non-inflammatory GI disorders. The IBD group displayed significantly lower rates of hyperlipidemia (8.6% vs. 30.3%, p<0.001), diabetes mellitus (DM) (10% vs. 24.8%, p<0.001), and hypertension (11.7% vs. 32.1%, p<0.001) compared to the non-IBD group. Only 2.7% (n=8) of IBD patients developed IHD. Logistic regression analysis did not demonstrate a significant association between IBD and IHD (p=0.932). Among classical risk factors, only hypertension (OR: 26.2, 95% CI: 2.14-661, p=0.016) and hyperlipidemia (OR: 10.5, 95% CI: 1.32-132, p=0.0405) significantly increased the risk of developing IHD among patients with IBD.
CONCLUSION: In this cohort, there is no increased risk of developing IHD in patients with IBD compared to non-IBD patients.
METHODS: A retrospective cohort analysis included patients with and without IBD seen at the outpatient gastroenterology clinic of a large tertiary care hospital between January 2015 and October 2022. The primary outcome was the association between IBD and IHD, and the secondary outcome was predictors of IHD in patients with IBD.
RESULTS: The study included 400 patients; 291 were IBD patients, and 109 had other non-inflammatory GI disorders. The IBD group displayed significantly lower rates of hyperlipidemia (8.6% vs. 30.3%, p<0.001), diabetes mellitus (DM) (10% vs. 24.8%, p<0.001), and hypertension (11.7% vs. 32.1%, p<0.001) compared to the non-IBD group. Only 2.7% (n=8) of IBD patients developed IHD. Logistic regression analysis did not demonstrate a significant association between IBD and IHD (p=0.932). Among classical risk factors, only hypertension (OR: 26.2, 95% CI: 2.14-661, p=0.016) and hyperlipidemia (OR: 10.5, 95% CI: 1.32-132, p=0.0405) significantly increased the risk of developing IHD among patients with IBD.
CONCLUSION: In this cohort, there is no increased risk of developing IHD in patients with IBD compared to non-IBD patients.