Clinical, cosmetic and investigational dermatology · 2026
Evaluation of VISIA-Derived Erythema Metrics Against Blinded Clinician Assessment After Intense Pulsed Light Therapy in Erythematotelangiectatic Rosacea: A Real-World Cohort Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fan Birao, Meng Xingye, Yu Ruixing
Аннотация
BACKGROUND: Erythematotelangiectatic rosacea (ETR) is characterized by persistent facial erythema, but objective evaluation of treatment response remains challenging. This study aimed to evaluate VISIA-derived erythema metrics against blinded clinician assessment and identify imaging-based thresholds associated with clinical improvement after intense pulsed light (IPL) therapy.
METHODS: This retrospective single-center real-world cohort study included 227 patients with ETR who completed three regular IPL sessions with paired baseline and post-treatment VISIA images. Three dermatologists independently performed blinded Clinician Erythema Assessment (CEA), and consensus scores were used as the clinical reference. Inter-rater reliability was assessed using quadratic weighted κ, and receiver operating characteristic (ROC) analysis with bootstrap resampling was performed to identify candidate VISIA thresholds corresponding to a ≥2-grade CEA reduction.
RESULTS: Blinded CEA demonstrated good-to-excellent reliability, with mean pairwise quadratic weighted κ values of 0.795 at baseline and 0.863 after treatment. VISIA erythema area, erythema concentration, and consensus CEA scores significantly improved after IPL therapy (all p<0.001). Changes in erythema area correlated more strongly with ΔCEA than erythema concentration (ρ=0.476 vs 0.308, both p<0.001). Percentage reduction in erythema area showed the highest discrimination for ≥2-grade CEA improvement (AUC=0.851; 95% CI, 0.797-0.901), with an optimal cutoff of 18.76% (sensitivity, 0.72; specificity, 0.93).
CONCLUSION: VISIA-derived erythema area reduction correlated with blinded clinician-assessed improvement and may serve as an objective adjunct for monitoring IPL response in ETR. The 18.76% threshold is exploratory and requires external validation. Patient-reported outcomes were unavailable and should be incorporated in future prospective studies.
METHODS: This retrospective single-center real-world cohort study included 227 patients with ETR who completed three regular IPL sessions with paired baseline and post-treatment VISIA images. Three dermatologists independently performed blinded Clinician Erythema Assessment (CEA), and consensus scores were used as the clinical reference. Inter-rater reliability was assessed using quadratic weighted κ, and receiver operating characteristic (ROC) analysis with bootstrap resampling was performed to identify candidate VISIA thresholds corresponding to a ≥2-grade CEA reduction.
RESULTS: Blinded CEA demonstrated good-to-excellent reliability, with mean pairwise quadratic weighted κ values of 0.795 at baseline and 0.863 after treatment. VISIA erythema area, erythema concentration, and consensus CEA scores significantly improved after IPL therapy (all p<0.001). Changes in erythema area correlated more strongly with ΔCEA than erythema concentration (ρ=0.476 vs 0.308, both p<0.001). Percentage reduction in erythema area showed the highest discrimination for ≥2-grade CEA improvement (AUC=0.851; 95% CI, 0.797-0.901), with an optimal cutoff of 18.76% (sensitivity, 0.72; specificity, 0.93).
CONCLUSION: VISIA-derived erythema area reduction correlated with blinded clinician-assessed improvement and may serve as an objective adjunct for monitoring IPL response in ETR. The 18.76% threshold is exploratory and requires external validation. Patient-reported outcomes were unavailable and should be incorporated in future prospective studies.