Scientific reports · 2017
Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Hailiang, Duggal Priya, Thio Chloe L, Latanich Rachel, Goedert James J, Mangia Alessandra, Cox Andrea L, Kirk Gregory D, Mehta Shruti, Aneja Jasneet, Alric Laurent, Donfield Sharyne M, Cramp Matthew E, Khakoo Salim I, Tobler Leslie H, Busch Michael, Alexander Graeme J, Rosen Hugo R, Edlin Brian R, Segal Florencia P, Lauer Georg M, Thomas David L, Daly Mark J, Chung Raymond T, Kim Arthur Y
Аннотация
Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.